Relationship between oral cancer and implants: clinical cases and systematic literature review
Relationship between oral cancer and implants: clinical cases and systematic literature review
Enrique Jané-Salas,1 José López-López,1 Xavier Roselló-Llabrés,1 Oscar-Francisco Rodríguez-Argueta,2 andEduardo Chimenos-Küstner1
Abstract
The use of implants for oral rehabilitation of edentulous spaces has recently been on the increase, which has also led to an increase in complications such as peri-implant inflammation or periimplantitis. Chronic inflammation is a risk factor for developing oral squamous cell carcinoma (OSCC). Objectives: To review the literature of cases that associate implant placement with the development of oral cancer. Study design: We present two clinical cases and a systematic review of literature published on the relationship between oral cancer and implants. Results: We found 13 articles published between the years 1996 and 2009, referencing 18 cases in which the osseointegrated implants are associated with oral squamous cell carcinoma. Of those, 6 articles were excluded because they did not meet the inclusion criteria. Of the 18 cases reported, only 7 cases did not present a previous history of oral cancer or cancer in other parts of the body. Conclusions: Based on the review of these cases, a clear cause-effect relationship cannot be established, although it can be deduced that there is a possibility that implant treatment may constitute an irritant and/or inflammatory cofactor which contributes to the formation and/or development of OSCC.
Key words: Cancer, oral cancer, dental implants, oral squamous cell carcinoma, dental implants complications.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448182/
